Tips
1. If your pig runs into his or her hut, try coaxing them out with a carrot.
2. If you are not sure about picking up your guinea pig, or if you want it to be a more pleasant experience for the both of you, try wrapping it up in a towel; some guinea pigs can get scared from being up in the air.
3. Guinea pigs have small digestive systems and bladders, and go the bathroom frequently. When holding them on your lap, be sure to place a folded towel under the guinea pig to keep yourself clean and the animal more comfortable.
4. Always supervise children picking up guinea pigs.

Source: Wiki-How